Structural characterization of the ICOS/ICOS-L immune complex reveals high molecular mimicry by therapeutic antibodies
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چکیده
منابع مشابه
Molecular mimicry and immune thrombocytopenia.
Immune thrombocytopenia is a common complication of infection with the human immunodeficiency (HIV)1 and hepatitis C (HCV)2 viruses. In previous works, the authors showed that many patients with HIVassociated thrombocytopenia have autoantibodies that recognize a restricted peptide sequence (GPIIIa49-66) in platelet membrane glycoprotein IIIa (GPIIIa) and can be recovered from patient plasma in ...
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Molecular mimicry and immune-mediated diseases.
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متن کاملMolecular Mimicry: Structural and Physiological Investigations
Introduction Independent molecules are expected to possess distinct three-dimensional structures. However, it is becoming increasingly evident that diverse biological molecules, particularly proteins, do not have entirely unrelated structural architectures, even when their functions are independent. It is apparent that the protein structural repertoire is generated from a finite number of struc...
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ژورنال
عنوان ژورنال: Nature Communications
سال: 2020
ISSN: 2041-1723
DOI: 10.1038/s41467-020-18828-4